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Other Concomitant Therapy Although specific interaction trials were not performed with other compounds, approximately 90 of day the subjects in the 3 randomized, double-blind, placebo-controlled safety and efficacy trials receiving avodart were taking other medications concomitantly. Therefore, avodart may cause fetal harm when administered to a pregnant woman. Statistically significant differences (avodart versus placebo) were noted day at the earliest posttreatment prostate volume measurement in each trial (Month 1, Month 3, or Month 6) and continued through Month. Similar changes were seen at Month 48: -27.3 (24.91) for combination therapy, -28.0 (25.74) for avodart, and.6 (35.45) for tamsulosin. In a clinical study of avodart men at increased risk of prostate cancer, men taking Avodart had a serious form of prostate cancer more often than day men who did not take Avodart. Avodart is not approved for the prevention of prostate cancer. Combination therapy was statistically superior to each of the monotherapy treatments in decreasing symptom score at Month 24, the primary time point for this day endpoint. In patients with BPH treated with dutasteride.5 mg/day for 4 years, the median decrease in serum DHT was 94 at 1 year, 93 at 2 years, and 95 at both 3 and 4 years. For more information, go to m or call. Women of childbearing potential see Warnings and Precautions (5.4 Use in Specific Populations (8.1). In human serum following dosing to steady state, unchanged dutasteride, 3 major metabolites (4-hydroxydutasteride, 1,2-dihydrodutasteride, and 6-hydroxydutasteride and 2 minor metabolites (6,4-dihydroxydutasteride and 15-hydroxydutasteride as assessed by mass spectrometric response, have been detected. The avodart average steady-state serum dutasteride concentration was 40 ng/mL following.5 mg/day for 1 year. These reactions have been chosen for inclusion due to a combination of their seriousness, frequency of reporting, or potential causal connection to avodart. The development day of male external genitalia of monkey offspring was not adversely affected. Effects on newborn startle response were noted at doses greater than or equal.5 mg/kg/day. In men with prostate volumes 40 cc, the mean decrease was -3.7 next units for dutasteride and -2.2 units for placebo, with a mean difference between the 2 treatment groups of -1.5 at Month 24. So you don't day waste a trip!, main Menu - -Our In Stock Brands -Douglas Fir? Effect On Maximum Urine Flow Rate The baseline Qmax was approximately.7 mL/sec for each treatment group. As the prostate grows, it can avodart lead to urinary problems, such as difficulty in passing urine and a need to go to the toilet frequently. Cholestyramine Administration of a single 5-mg dose of Avodart followed 1 hour later by 12 g of cholestyramine does not affect the relative bioavailability of dutasteride see Clinical Pharmacology (12.3). Each capsule contains.5 mg dutasteride. Do not chew or break open the capsule. Effects On Other Hormones In healthy volunteers, 52 weeks of treatment with dutasteride.5 mg/day (n avodart 26) resulted in no clinically significant change compared with placebo day (n 23) in sex hormone-binding globulin, estradiol, luteinizing hormone, follicle-stimulating hormone, thyroxine day (free T4 and dehydroepiandrosterone. When including the open-label extensions, 1,009 male subjects were exposed to Avodart for 3 years and 812 were exposed for 4 years. You day can also opt out by visiting. In men aged 50 to 75 years with a prior negative biopsy for prostate cancer and a baseline PSA between.5 ng/mL and.0 ng/mL taking Avodart in the 4-year Reduction by Dutasteride of Prostate Cancer Events (reduce) trial, there was an increased. The highest measured semen concentration of dutasteride in treated men was 14 ng/mL. During the double-blind treatment period, 2,167 male subjects were exposed to Avodart, including 1,772 exposed for 1 year and 1,510 day exposed for 2 years.

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